Intravitreal sustained release of VEGF causes retinal neovascularization in rabbits and breakdown of the blood-retinal barrier in rabbits and primates.

@article{Ozaki1997IntravitrealSR,
  title={Intravitreal sustained release of VEGF causes retinal neovascularization in rabbits and breakdown of the blood-retinal barrier in rabbits and primates.},
  author={Hiroshi Ozaki and Hideyuki Hayashi and Stanley A. Vinores and Y Moromizato and Peter Anthony Campochiaro and Kenji Oshima},
  journal={Experimental eye research},
  year={1997},
  volume={64 4},
  pages={505-17}
}
Vascular endothelial growth factor (VEGF) has been identified as a possible mediator of retinal neovascularisation (NV), but it is not certain if VEGF alone is sufficient to cause retinal NV. We sought to investigate this issue by implanting ethylene-vinyl acetate copolymer pellets that slowly release VEGF into the vitreous cavity of rabbits and primates. Eyes were examined by indirect ophthalmoscopy, fundus photography, and fluorescein angiography and then animals were killed at various time… CONTINUE READING
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