Intravitreal melphalan for persistent or recurrent retinoblastoma vitreous seeds: preliminary results.

  title={Intravitreal melphalan for persistent or recurrent retinoblastoma vitreous seeds: preliminary results.},
  author={Carol L Shields and Fairooz Puthiyapurayil Manjandavida and Sruthi A Arepalli and Swathi Kaliki and Sara E. Lally and Jerry A. Shields},
  journal={JAMA ophthalmology},
  volume={132 3},
IMPORTANCE Recurrent or persistent vitreous seeds following treatment of retinoblastoma poses difficult management and often leads to enucleation. OBJECTIVE To describe the technique and evaluate the efficacy and complications of intravitreal melphalan for vitreous seeding from retinoblastoma. DESIGN, SETTING, AND PARTICIPANTS This retrospective noncomparative analysis was conducted at a tertiary referral center. The study included 11 consecutive eyes of 11 patients with viable persistent… CONTINUE READING


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