Intravitreal liposome-encapsulated trifluorothymidine in a rabbit model.

  title={Intravitreal liposome-encapsulated trifluorothymidine in a rabbit model.},
  author={K. R. Liu and Gholam A. Peyman and Bahram Khoobehi and H M Alkan and Richard G Fiscella},
  volume={94 9},
Two groups of albino rabbits received an intravitreal injection of liposome-encapsulated trifluorothymidine. One group underwent a clearance study using high-performance liquid chromatography. The results of this study demonstrated a prolonged vitreal drug level within the range of ID50 for many strains of herpesvirus and human cytomegalovirus (CMV) at 28 days after injection. The eyes of another group were evaluated with preoperative and postoperative indirect ophthalmoscopy… CONTINUE READING


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