Intravitreal injection of the heparin analog 5-amino-2-naphthalenesulfonate reduces retinal neovascularization in mice.

@article{Lange2007IntravitrealIO,
  title={Intravitreal injection of the heparin analog 5-amino-2-naphthalenesulfonate reduces retinal neovascularization in mice.},
  author={Clemens A Lange and Christoph Ehlken and Gottfried Martin and Kirstin Konzok and Jaime Moscoso Del Prado and Lutz Lothar Hansen and Hansjuergen Thomas Agostini},
  journal={Experimental eye research},
  year={2007},
  volume={85 3},
  pages={323-7}
}
The effect of the heparin analog 5-amino-2-naphthalenesulfonate (5-amino-2-NMS) on retinal neovascularization was investigated in the mouse model for oxygen-induced retinopathy (OIR). From postnatal day 7 (P7) until P12, mice were kept in a 75% oxygen environment. On P12, they received an intravitreal injection of 10mM 5-amino-2-NMS in one eye and PBS as control substance in the fellow eye. The animals were intracardially perfused with fluorescein-dextran solution on P17. Retinal whole mounts… CONTINUE READING
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