Intravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina.

@article{Beltran2007IntravitrealIO,
  title={Intravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina.},
  author={William Anthony Beltran and Rong Wen and Gregory M. Acland and Gustavo D. Aguirre},
  journal={Experimental eye research},
  year={2007},
  volume={84 4},
  pages={753-71}
}
Ciliary neurotrophic factor (CNTF) rescues photoreceptors in several animal models of retinal degeneration and is currently being evaluated as a potential treatment for retinitis pigmentosa in humans. This study was conducted to test whether CNTF prevents photoreceptor cell loss in XLPRA2, an early onset canine model of X-linked retinitis pigmentosa caused by a frameshift mutation in RPGR exon ORF15. Four different treatment regimens of CNTF were tested in XLPRA2 dogs. Under anesthesia, the… CONTINUE READING
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Negative regulation of phototransduction machinery by CNTF is likely through the photostasis mechanism

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  • 2005
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Comparative Biomedical Sciences

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