Intravitreal daunomycin induces multidrug resistance in proliferative vitreoretinopathy.

  title={Intravitreal daunomycin induces multidrug resistance in proliferative vitreoretinopathy.},
  author={Peter Esser and D Tervooren and Klaus Heimann and Norbert Kociok and K. U. Bartz-Schmidt and Peter Walter and Michael Weller},
  journal={Investigative ophthalmology & visual science},
  volume={39 1},
PURPOSE Adjuvant intravitreal daunomycin is frequently used for the management of proliferative vitreoretinopathy (PVR). In this study the authors examined whether daunomycin could induce multidrug resistance (MDR), mediated by the mdr-1 gene product P-glycoprotein, in the cells responsible for reproliferation in vivo and in human retinal pigment epithelial (RPE) cells in vitro. METHODS Expression of P-glycoprotein was examined by immunohistochemistry in surgically removed epiretinal… CONTINUE READING
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