Intravital imaging of mouse urothelium reveals activation of extracellular signal‐regulated kinase by stretch‐induced intravesical release of ATP

@inproceedings{Sano2016IntravitalIO,
  title={Intravital imaging of mouse urothelium reveals activation of extracellular signal‐regulated kinase by stretch‐induced intravesical release of ATP
},
  author={Takeshi Sano and Takashi Kobayashi and Hiromitsu Negoro and Atsushi Sengiku and Takuya Hiratsuka and Yuji Kamioka and Louis S. Liou and Osamu Ogawa and Michiyuki Matsuda},
  booktitle={Physiological reports},
  year={2016}
}
To better understand the roles played by signaling molecules in the bladder, we established a protocol of intravital imaging of the bladder of mice expressing a Förster/fluorescence resonance energy transfer (FRET) biosensor for extracellular signal-regulated kinase (ERK), which plays critical roles not only in cell growth but also stress responses. With an upright two-photon excitation microscope and a vacuum-stabilized imaging window, cellular ERK activity was visualized in the whole bladder… CONTINUE READING
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