Intravital imaging of embryonic and tumor neovasculature using viral nanoparticles

  title={Intravital imaging of embryonic and tumor neovasculature using viral nanoparticles},
  author={H. Leong and N. Steinmetz and Amber L Ablack and G. Destito and A. Zijlstra and H. Stuhlmann and M. Manchester and J. D. Lewis},
  journal={Nature Protocols},
  • H. Leong, N. Steinmetz, +5 authors J. D. Lewis
  • Published 2010
  • Biology, Medicine
  • Nature Protocols
  • Viral nanoparticles are a novel class of biomolecular agents that take advantage of the natural circulatory and targeting properties of viruses to allow the development of therapeutics, vaccines and imaging tools. We have developed a multivalent nanoparticle platform based on the cowpea mosaic virus (CPMV) that facilitates particle labeling at high density with fluorescent dyes and other functional groups. Compared with other technologies, CPMV-based viral nanoparticles are particularly suited… CONTINUE READING
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