Intravital imaging of embryonic and tumor neovasculature using viral nanoparticles

@article{Leong2010IntravitalIO,
  title={Intravital imaging of embryonic and tumor neovasculature using viral nanoparticles},
  author={Hon Sing Leong and Nicole F Steinmetz and Amber L Ablack and Giuseppe Destito and Andries Zijlstra and Heidi Stuhlmann and Marianne Manchester and John D. Lewis},
  journal={Nature Protocols},
  year={2010},
  volume={5},
  pages={1406-1417}
}
Viral nanoparticles are a novel class of biomolecular agents that take advantage of the natural circulatory and targeting properties of viruses to allow the development of therapeutics, vaccines and imaging tools. We have developed a multivalent nanoparticle platform based on the cowpea mosaic virus (CPMV) that facilitates particle labeling at high density with fluorescent dyes and other functional groups. Compared with other technologies, CPMV-based viral nanoparticles are particularly suited… CONTINUE READING

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