Intravital Fluorescence Excitation in Whole-Animal Optical Imaging.

Abstract

Whole-animal fluorescence imaging with recombinant or fluorescently-tagged pathogens or cells enables real-time analysis of disease progression and treatment response in live animals. Tissue absorption limits penetration of fluorescence excitation light, particularly in the visible wavelength range, resulting in reduced sensitivity to deep targets. Here, we… (More)
DOI: 10.1371/journal.pone.0149932

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