Intravesical thermo-chemotherapy based on conductive heat: a first pharmacokinetic study with Mitomycin C in superficial transitional cell carcinoma patients

@article{Milla2014IntravesicalTB,
  title={Intravesical thermo-chemotherapy based on conductive heat: a first pharmacokinetic study with Mitomycin C in superficial transitional cell carcinoma patients},
  author={Paola Milla and Chiara Fiorito and Shahrokh F Shariat and Silvia Arpicco and Luigi Cattel and Paulo Gontero},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2014},
  volume={73},
  pages={503-509}
}
To evaluate, for the first time, the mitomycin C (MMC) pharmacokinetics during intravesical hyperthermia treatment based on conductive heat and the stability and recovery of the drug at the end of the instillation period. Eleven patients with recurrent intermediate-risk superficial transitional cell carcinoma of the bladder were treated weekly for six cycles with intravesical MMC (40 mg MMC in 50 ml) in local hyperthermia (45 °C) with Unithermia® system. Each instillation lasted 45 min, with… CONTINUE READING
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