Intravesical drug delivery for dysfunctional bladder

@article{Hsu2013IntravesicalDD,
  title={Intravesical drug delivery for dysfunctional bladder},
  author={Chun-Chien Hsu and Yao-Chi Chuang and Michael B. Chancellor},
  journal={International Journal of Urology},
  year={2013},
  volume={20}
}
The bladder is a hollow organ that can be treated locally by transurethral catheter for intravesical drug instillation or cystoscopy for intravesical drug injection. With advancing technology, local organ‐specific therapy and drug delivery is of expanding interest for treating dysfunctional bladder, including interstitial cystitis/bladder pain syndrome, overactive bladder and sterile hemorrhagic cystitis after chemotherapy or pelvic radiation. Intravesical therapy has shown varying degrees of… 
View on Wiley
tmua.org.tw
36 Citations
Background Citations
16
Methods Citations
3

36 Citations

Citation Type

Citation Type

Editorial Comment from Dr Saito and Dr Shimizu to Intravesical drug delivery for dysfunctional bladder
  • M. Saito, S. Shimizu
  • Medicine
    International journal of urology : official journal of the Japanese Urological Association
  • 2013
TLDR
Future research and development of novel drug delivery systems as a delivery platform for intravesical administration of drugs can improve the efficacy and safety of pharmacotherapy for dysfunctional bladder including OAB, IC/BPS and HC.
Biomaterial-assisted drug delivery for interstitial cystitis/bladder pain syndrome treatment.
TLDR
The pathogenesis and animal models of IC/BPS, a chronic and painful bladder condition afflicting patients with increased urinary urgency and frequency as well as incontinence, are elucidated and recent representative biomaterial-assisted drug delivery systems for IC/ BPS treatment are highlighted.
Role of liposome in treatment of overactive bladder and interstitial cystitis
Current status of the development of intravesical drug delivery systems for the treatment of bladder cancer
TLDR
This review addresses the limitations of conventional therapeutic regimens and reports the use of polymeric hydrogels and nano/microcarriers for enhanced intravesical drug delivery in bladder cancer.
Bridging pharmacotherapy and minimally invasive surgery in interstitial cystitis/bladder pain syndrome treatment
TLDR
Interstitial cystitis/bladder pain syndrome is still a pathophysiological enigma with multifactorial etiopathogenesis that may be controlled but not completely cured, so combined phenotypic categorization with specific biomarkers could help toward better treatment.
Bladder instillation of liposome encapsulated onabotulinumtoxina improves overactive bladder symptoms: a prospective, multicenter, double-blind, randomized trial.
Investigational drugs for bladder pain syndrome (BPS) / interstitial cystitis (IC)
TLDR
The authors believe that new drugs developed for BPS/IC are more likely to meet their predetermined clinical endpoints if the inclusion/exclusion criterion is tailored to specific phenotype of B PS/IC patients.
Advances in intravesical therapy for bladder pain syndrome (BPS)/interstitial cystitis (IC)
TLDR
Although no definitive treatment is currently available for IC/BPS, various intravesical therapies are used, including heparin, hyaluronic acid, chondroitin sulfate, pentosan polysulfate, dimethylsulfoxide, liposomes, and botulinum onabotulinumtoxinA (BoNT‐A).
Intravesical treatment of bladder pain syndrome/interstitial cystitis: from the conventional regimens to the novel botulinum toxin injections
TLDR
There is no consensus regarding the best dosage scheme of BTX, the injection sites and the treatment intervals, yet BTX intravesical administration in patients with BPS/IC is a safe and efficient treatment option; yet the level of evidence of the initial studies is not high.
Potential Effect of Liposomes and Liposome-Encapsulated Botulinum Toxin and Tacrolimus in the Treatment of Bladder Dysfunction
TLDR
This review will present new developments on instillations of liposomes and liposome-encapsulated drugs into the urinary bladder for treating lower urinary tract dysfunction.
...
1
2
3
4
...

References

SHOWING 1-10 OF 90 REFERENCES
Intravesical therapy for lower urinary tract symptoms
Intravesical Treatments of Bladder Cancer: Review
TLDR
This review summarizes the pharmacological principles and the current status of intravesical therapy, and the application of computation to optimize the drug delivery to target sites and the treatment efficacy.
State of the art in intravesical therapy for lower urinary tract symptoms.
TLDR
A bird's eye view into the current status of intravesical therapy, with emphasis on liposomal nanoparticles, in diseases associated with lower urinary tract symptoms (LUTS) is taken.
Intravesical drug delivery: Challenges, current status, opportunities and novel strategies.
Intravesical Drug Delivery
TLDR
Recurrence rates in patients with superficial bladder cancer have been substantially reduced by combined transurethral resection and intravesicals pharmacotherapy, and the low systemic availability of most intravesical agents is consistent with the low frequency of acute and delayed systemic adverse effects.
Intravesical treatments for painful bladder syndrome/ interstitial cystitis.
TLDR
The evidence base for treating PBS/IC using intravesical preparations is limited, the potential for meta-analysis reduced by variation in the outcome measures used, and evidence is most promising for BCG and oxybutin instillation.
Intravesical liposome versus oral pentosan polysulfate for interstitial cystitis/painful bladder syndrome.
New frontiers in intravesical therapies and drug delivery.
Safety and dose flexibility clinical evaluation of intravesical liposome in patients with interstitial cystitis or painful bladder syndrome
Sustained Intravesical Drug Delivery Using Thermosensitive Hydrogel
TLDR
It is shown that PEG-PLGA-PEG polymer could be used as a viable sustained drug delivery system for intravesical therapy of diseases of the bladder such as cystitis using misoprostol using thermosensitive hydrogel in place of FITC.
...
1
2
3
4
5
...