Intravesical drug delivery: Challenges, current status, opportunities and novel strategies.


The urinary bladder has certain unique anatomical features which enable it to form an effective barrier to toxic substances diffusing from the urine into the blood. The barrier function is due to the epithelial surface of the urinary bladder, the urothelium, which has characteristic umbrella cells, joined by tight junctions and covered by impenetrable… (More)
DOI: 10.1016/j.jconrel.2010.08.031


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