Intravesical chemotherapy. Studies on the relationship between pH and cytotoxicity.

@article{Groos1986IntravesicalCS,
  title={Intravesical chemotherapy. Studies on the relationship between pH and cytotoxicity.},
  author={Erich Groos and Larry R. Walker and John R. W. Masters},
  journal={Cancer},
  year={1986},
  volume={58 6},
  pages={1199-203}
}
The influence of pH on the antitumor activity of drugs used for intravesical chemotherapy was studied. A human continuous cell line derived from a transitional cell carcinoma of the bladder was exposed to 6 drugs (Adriamycin [doxorubicin], cisplatin, epirubicin, epodyl, mitomycin C, and thiotepa) for 1 hour at 11 pH values ranging from 5.2 to 9.7, and cytotoxicity was measured by inhibition of colony formation. pH had a marked influence on drug activity: cisplatin, mitomycin C, and thiotepa… CONTINUE READING

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