Intravesical adriamycin instillations--what happens to the drug?

Abstract

Intravesical instillations of ADM have local and systemic effects: Locally a chemocystitis can be seen with a frequency of 10 - 40%. It can usually be treated conservatively and only rarely the therapy has to be discontinued. Urothelial dysplasia, proliferation and - in rats - the development of epithelial bladder tumors following repeated instillation need… (More)

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