Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer.

@article{Nogawa2005IntravesicalAO,
  title={Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer.},
  author={M. Nogawa and T. Yuasa and S. Kimura and Motoyoshi Tanaka and J. Kuroda and Kiyoshi Sato and A. Yokota and H. Segawa and Y. Toda and S. Kageyama and T. Yoshiki and Y. Okada and T. Maekawa},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 4},
  pages={
          978-85
        }
}
The mainstay in the management of invasive bladder cancer continues to be radical cystectomy. With regard to improvement of quality of life, however, therapies that preserve the bladder are desirable. We investigated the use of intravesical PLK-1 small interfering RNA (siRNA) against bladder cancer. Patients with bladder cancers expressing high levels of PLK-1 have a poor prognosis compared with patients with low expression. Using siRNA/cationic liposomes, the expression of endogenous PLK-1… Expand
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