Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer.

Abstract

The mainstay in the management of invasive bladder cancer continues to be radical cystectomy. With regard to improvement of quality of life, however, therapies that preserve the bladder are desirable. We investigated the use of intravesical PLK-1 small interfering RNA (siRNA) against bladder cancer. Patients with bladder cancers expressing high levels of… (More)

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Cite this paper

@article{Nogawa2005IntravesicalAO, title={Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer.}, author={Masaki Nogawa and Takeshi Yuasa and Shinya Kimura and Motoyoshi Tanaka and Junya Kuroda and Kiyoshi Sato and Asumi Yokota and Hidekazu Segawa and Yoshinobu Toda and Susumu Kageyama and Tatsuhiro Yoshiki and Yusaku Okada and Taira Maekawa}, journal={The Journal of clinical investigation}, year={2005}, volume={115 4}, pages={978-85} }