• Medicine
  • Published in
    Molecular therapy : the…
    2004

Intravesical Ad-IFNalpha causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFN-alpha protein.

@article{Benedict2004IntravesicalAC,
  title={Intravesical Ad-IFNalpha causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFN-alpha protein.},
  author={William F. Benedict and Ziming Tao and Chang-Soo Kim and Xin-qiao Zhang and Jain-Hua Zhou and Liana Adam and David James McConkey and Angela Papageorgiou and Mark F Munsell and Jennifer Philopena and Heidrun Engler and William Demers and Daniel C. Maneval and Colin P N Dinney and Robert James Connor},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2004},
  volume={10 3},
  pages={
          525-32
        }
}
We have produced prolonged, high local concentrations of interferon in vivo by intravesical instillation of adenoviruses encoding interferon-alpha (Ad-IFNalpha) together with the gene transfer-enhancing agent Syn3. We found sustained interferon protein levels for days, both in normal mouse urothelium and in human bladder cancer cells growing as superficial bladder tumors in nude mice using an orthotopic bladder model developed by us. Tumor burden in the bladder was determined utilizing cancer… CONTINUE READING

Citations

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