Intravesical ALT-803 and BCG Treatment Reduces Tumor Burden in a Carcinogen Induced Bladder Cancer Rat Model; a Role for Cytokine Production and NK Cell Expansion

@inproceedings{GomesGiacoia2014IntravesicalAA,
  title={Intravesical ALT-803 and BCG Treatment Reduces Tumor Burden in a Carcinogen Induced Bladder Cancer Rat Model; a Role for Cytokine Production and NK Cell Expansion},
  author={Evan Gomes-Giacoia and Makito Miyake and Steve Goodison and Aravindhan Sriharan and Ge Zhang and Lijing You and Jack O. Egan and Peter R. Rhode and Alexander Scott Parker and Karl X. Chai and Hing Choi Wong and Charles J Rosser},
  booktitle={PloS one},
  year={2014}
}
Intravesical Bacillus Calmette-Guérin (BCG) has been shown to induce a specific immunologic response (i.e., activation of IL-2 and effector T-cells), while preclinical studies using ALT-803 (mutated IL-15 analogue combined with IL-15Rα-Fc fusion) have shown promising results by prolonging the agent's half-life and stimulating CD8+ T-cells. Based on these results, we hypothesized that the intravesical administration of ALT-803 along with BCG will generate an immunologic response leading to… CONTINUE READING
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National Comprehensive Cancer Network (NCCN). Bladder cancer

  • PE Clark, N Agarwal, MC Biagioli, MA Eisenberger, RE Greenberg
  • J Natl Compr Canc Netw
  • 2013

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