Intraventricular insulin and leptin reverse place preference conditioned with high-fat diet in rats.

@article{Figlewicz2004IntraventricularIA,
  title={Intraventricular insulin and leptin reverse place preference conditioned with high-fat diet in rats.},
  author={Dianne P. Figlewicz and Jennifer N. Bennett and Scott B. Evans and Karl K Kaiyala and Alfred J. Sipols and Stephen C. Benoit},
  journal={Behavioral neuroscience},
  year={2004},
  volume={118 3},
  pages={479-87}
}
The authors hypothesized that insulin and leptin, hormones that convey metabolic and energy balance status to the central nervous system (CNS), decrease the reward value of food, as assessed by conditioned place preference (CPP). CPP to high-fat diet was blocked in ad-lib fed rats given intraventricular insulin or leptin throughout training and test or acutely before the test. Insulin or leptin given only during the training period did not block CPP. Thus, elevated insulin and leptin do not… CONTINUE READING

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