Intraventricular infusion of the neurotrophic protein S100B improves cognitive recovery after fluid percussion injury in the rat.

@article{Kleindienst2004IntraventricularIO,
  title={Intraventricular infusion of the neurotrophic protein S100B improves cognitive recovery after fluid percussion injury in the rat.},
  author={Andrea Kleindienst and Harlan B Harvey and Ann C. Rice and Christian Mueller and Robert J Hamm and Michael Robert Gaab and Malcolm Ross Bullock},
  journal={Journal of neurotrauma},
  year={2004},
  volume={21 5},
  pages={541-7}
}
Elevated serum S100B levels have been shown to be a predictor of poor outcome after traumatic brain injury (TBI). Experimental data, on the other hand, demonstrate a neuroprotective and neurotrophic effect of this calcium-binding protein. The purpose of this study was to examine the role of increased S100B levels on functional outcome after TBI. Following lateral fluid percussion or sham injury in male Sprague Dawley rats (n = 56), we infused S100B (50 ng/h) or vehicle into the cerebrospinal… CONTINUE READING

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