Intraventricular administration of amikacin for complicated Gram-negative meningitis and ventriculitis.

@article{Wirt1979IntraventricularAO,
  title={Intraventricular administration of amikacin for complicated Gram-negative meningitis and ventriculitis.},
  author={T. C. Wirt and Z. McGee and E. Oldfield and W. Meacham},
  journal={Journal of neurosurgery},
  year={1979},
  volume={50 1},
  pages={
          95-9
        }
}
Four pediatric neurosurgical patients with Gram-negative meningitis and ventriculitis were treated with parenteral and intraventricular amikacin, a new aminoglycoside. The organisms infecting these patients were resistant to multiple antimicrobial drugs but were sensitive to amikacin. Treatment was continued for 14 days after cerebrospinal fluid cultures became negative. All four patients were cured and have demonstrated no nephrotoxicity, ototoxicity, or evidence of persistent infection on… Expand
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