Intraventricular Administration of BDNF Increases the Number of Newly Generated Neurons in the Adult Olfactory Bulb

  title={Intraventricular Administration of BDNF Increases the Number of Newly Generated Neurons in the Adult Olfactory Bulb},
  author={Tanja Zigova and Viorica Pencea and Stanley J. Wiegand and Marla B. Luskin},
  journal={Molecular and Cellular Neuroscience},
We have previously demonstrated that the most rostral part of the subventricular zone (SVZ) is a source of neuronal progenitor cells whose progeny are destined to become interneurons of the olfactory bulb. To determine whether the number of newly generated neurons in the adult olfactory bulb could be increased by the administration of an exogenous factor, brain-derived neurotrophic factor (BDNF) was infused for 12 days into the right lateral ventricle of adult rat brains. The production of new… 
Infusion of Brain-Derived Neurotrophic Factor into the Lateral Ventricle of the Adult Rat Leads to New Neurons in the Parenchyma of the Striatum, Septum, Thalamus, and Hypothalamus
The results demonstrate that the adult brain parenchyma may recruit and/or generate new neurons, which could replace those lost as a result of injury or disease.
Intraventricular Infusion of TrkB-Fc Fusion Protein Promotes Ischemia-Induced Neurogenesis in Adult Rat Dentate Gyrus
Evidence is provided that endogenous BDNF counteracts neuronal differentiation, but not cell proliferation or survival, in ischemia-induced dentate gyrus neurogenesis, in the dentate subgranular zone and granule cell layer.
Decreased neurogenesis after cholinergic forebrain lesion in the adult rat
It is proposed that the cholinergic system plays a survival‐promoting role for neuronal progenitors and immature neurons within regions of adult neurogenesis, similar to effects observed previously during brain development.
Chemical characterization of newly generated neurons in the striatum of adult primates
It is demonstrated that a single injection of AdBDNF increases the number of newborn neurons into adult primate striatum and that newborn striatal neurons exhibit the chemical phenotype of medium-spiny projection neurons, which are specifically targeted in Huntington’s disease.
Neurogenesis in the Subventricular Zone and Rostral Migratory Stream of the Neonatal and Adult Primate Forebrain
It is demonstrated that the primate fore brain, similar to the rodent forebrain, harbors a specialized population of mitotically active neuronal progenitor cells that undergo extensive rearrangements while continuing to proliferate throughout life.
PSA-NCAM in postnatally generated immature neurons of the olfactory bulb: a crucial role in regulating p75 expression and cell survival
It is shown that the polysialylated isoforms of the neural cell adhesion molecule (PSA-NCAM) act as a pro-survival molecule in immature newborn neurons, and proposed that PSA- NCAM may promote survival by controlling the expression of the p75 receptor in developing neurons.
Adenoviral Brain-Derived Neurotrophic Factor Induces Both Neostriatal and Olfactory Neuronal Recruitment from Endogenous Progenitor Cells in the Adult Forebrain
A single injection of adenoviral BDNF substantially augmented the recruitment of new neurons into both neurogenic and non-neurogenic sites in the adult rat brain, suggesting the intraventricular delivery of, and ependymal infection by, viral vectors encoding neurotrophic agents may be a feasible strategy for inducing neurogenesis from resident progenitor cells in theadult brain.


Neuronal precursors of the adult rat subependymal zone persist into senescence, with no decline in spatial extent or response to BDNF.
The neuronal precursors of the rat brain persist into senescence; the size of the precursor pool attenuates minimally with age, and its spatial extent remains constant.
Distribution of Intracerebral Ventricularly Administered Neurotrophins in Rat Brain and Its Correlation with Trk Receptor Expression
Data suggest that the presence of the trkB receptor on the ependymal layer of the ventricle and its expression throughout the brain parenchyma represents a significant impediment to the adequate diffusion of ICV-injected BDNF into the brain for delivery to target neurons.
Brain-derived neurotrophic factor promotes the survival of neurons arising from the adult rat forebrain subependymal zone.
BDNF supports the survival of neurons produced by the adult rat forebrain and may act as a permissive factor for neuronal recruitment in adulthood.
Comparative Strategies of Subependymal Neurogenesis in the Adult Forebrain
The persistence into adulthood of a relatively widespread pool of SZ progenitor cells that remain neurogenic in selected regions but more generally become vestigial is suggested, perhaps as a result of the loss of permissive signals for daughter cell migration and/or survival in the local environment.
BDNF enhances the differentiation but not the survival of CNS stem cell- derived neuronal precursors
It is suggested that BDNF markedly enhances the antigenic and morphologic differentiation of EGF-generated neuronal precursors and is not sufficient for preventing their death over time.
In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain
In vivo results confirm the existence of EGF-responsive subependymal neural precursor cells in the adult mouse forebrain and suggest that EGF acts directly as a proliferation, survival, and migration factor for subdependymal precursor cells to expand these populations and promote the movement of these cells into normal brain parenchyma.
Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb
  • J. Altman
  • Biology
    The Journal of comparative neurology
  • 1969
The results established that the major target structure of cell production in the subependymal layer of the lateral ventricle in young‐adult rats is the olfactory bulb, with only moderate contribution made to the anterior neocortex and basal ganglia.