Intraventricular 6-hydroxydopamine lowers isolation-induced fighting behavior in male mice.


Male mice with high isolation-induced fighting tendencies were administered 200 mug 6-OHDA or vehicle intraventricularly and tested for fighting tendency for up to 10 weeks until sacrifice, and assayed for brain NE levels. A strong correlation was found between NE depletion and reduced fighting tendency after 6-OHDA treatment. The depressed fighting by mice… (More)


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