Intraventricular α-interferon in subacute sclerosing panencephalitis

  title={Intraventricular $\alpha$-interferon in subacute sclerosing panencephalitis},
  author={Carlo Cianchetti and Maria Giovanna Marrosu and Francesco Muntoni and Anna Lisa Fratta and Alessandro Zuddas},
  pages={315 - 315}
To the Editor: Anlar et al.1 reported the favorable effect of intraventricular (IVC) human α-interferon (IFN) plus isoprinosine in subacute sclerosing panencephalitis (SSPE). Theirα-IFN treatment regimen consisted of a 6-week course, 5-day/week administration, with a total of 30 × 106 U/m2 (5× 106 U/m2 each week); in some cases (not specified how many), the course was repeated at 2- to 6-month intervals, up to 6 times. We wonder whether better results could be obtained by a more prolonged… Expand
α-Interferon and isoprinosine in adult-onset subacute sclerosing panencephalitis
Treatment with oral isoprinosine plus α-interferon is effective for SSPE, and one patient died within two months, and the disease progressed in three patients. Expand
Subacute sclerosing panencephalitis
  • R. Garg
  • Medicine
  • Postgraduate medical journal
  • 2002
A combination of oral isoprinosine (Inosiplex) and intraventricular interferon alfa appears to be the best effective treatment for subacute sclerosing panencephalitis. Expand
A serial ¹⁸FDG-PET study of a patient with SSPE who had good prognosis by combination therapy with interferon alpha and ribavirin.
  • T. Ohya, Y. Yamashita, +6 authors T. Matsuishi
  • Medicine
  • European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
  • 2014
It is considered that combination therapy in the very early stage without hypometabolism in the cerebral cortex may be effective for SSPE. Expand
Role of CSF serology in follow-up of subacute sclerosing panencephalitis patients on treatment.
An unusual case of adult onset SSPE patient on treatment with significant clinical improvement, even in the absence of conversion to seronegativity in either CSF or serum, on follow-up serological examination is reported. Expand
Interferon therapy-responsive brain metabolic abnormalities in a case of adult-onset subacute sclerosing panencephalitis evaluated by 1H MRS analysis
Intraventricular interferon injection plus oral inosine pranobex treatment produced a substantial improvement in the MRS findings, suggesting the validity of monitoring MRS in SSPE, and suggesting neuronal loss and reactive gliosis without inflammation. Expand
Subacute Sclerosing Panencephalitis: Results of the Canadian Paediatric Surveillance Program and review of the literature
The CPSP has demonstrated that Canadian paediatricians and paediatric neurologists may encounter cases of subacute Sclerosing Panencephalitis and provides a review of the disease and its management. Expand
Neuropeptide Y Counteracts Interferon-Alpha-Induced Anorexia
The hypothesis that an endogenous feeding-enhancing peptide, neuropeptide Y (NPY), could inhibit IFN-α-induced anorexia in rats is tested and it is suggested that NPY and its agonists could represent a potential novel intervention for IFn-α immunotherapy-associatedAnorexia. Expand
Measles and Its Neurological Complications
Although the incidence of measles has declined substantially since the introduction of live attenuated vaccines, it is still a disease of worldwide importance [1]. With about 900,000 deaths per year,Expand


Subacute sclerosing panencephalitis: remission after treatment with intraventricular interferon
Three children with stage II-III subacute sclerosing panencephalitis (SSPE) were treated with intraventricular human leukocyte interferon for 6 months. All three improved to varying degrees and forExpand
Immunological Parameters in Subacute Sclerosing Panencephalitis and the Effect of Intraventricular Interferon
Subacute sclerosing panencephalitis (SSPE) is a late, fatal complication of measles infection. From the immunological point of view, it seems to us that two problems are of main interest in SSPE. TheExpand
The Turkish immigrant households and families in Melbourne, Australia.
An exploratory analysis of household structure of the sampled migrants not only offered a basis to develop a typology of Turkish migrant families but also became the initial step in discussing some aspects of the parents' concern for their children in Australia. Expand
Detection of measles virus
  • RNA January
  • 1998
30-year old hospital dining facility gets a facelift.
Long-term follow-up of patients with subacute sclerosing panencephalitis treated with intraventricular a-interferon
  • Neurology
  • 1997
Combined oral isoprinosineintraventricular a-interferon therapy for subacute sclerosing panencephalitis
  • Brain Dev 1993;15:346-355
  • 1993
Detection of measles virus RNA