Intravenously delivered glucocorticoid liposomes inhibit osteoclast activity and bone erosion in murine antigen-induced arthritis.

@article{Hofkens2011IntravenouslyDG,
  title={Intravenously delivered glucocorticoid liposomes inhibit osteoclast activity and bone erosion in murine antigen-induced arthritis.},
  author={Wouter Hofkens and Lilyanne C Grevers and Birgitte Walgreen and Teun J de Vries and Pieter J. M. Leenen and Vincent E Everts and Gert Storm and Wim B. van den Berg and Peter L van Lent},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2011},
  volume={152 3},
  pages={
          363-9
        }
}
  • Wouter Hofkens, Lilyanne C Grevers, +6 authors Peter L van Lent
  • Published in
    Journal of controlled release…
    2011
  • Chemistry, Medicine
  • UNLABELLED The objective of this study was to determine the effect of systemic delivery of prednisolone phosphate (PLP) encapsulated within long circulating 'stealth' liposomes on bone erosion and osteoclast activity during experimental antigen-induced arthritis (AIA). Liposomal PLP strongly suppressed knee joint swelling, synovial infiltrate and bone erosion in antigen-induced arthritis. The number of active osteoclasts was not only suppressed in bone lesions near inflamed synovium, but also… CONTINUE READING

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