Intravenous-to-oral switch in anticancer chemotherapy: a focus on docetaxel and paclitaxel.


Oral administration of the taxanes docetaxel and paclitaxel is hampered by their affinity for drug transporters, especially ABCB1 (P-glycoprotein, Pgp); extensive first-pass metabolism by cytochrome P450 3A (CYP3A); and poor drug solubility. Preclinical studies in Pgp-deficient and wild-type mice demonstrated that modulation of either Pgp or CYP3A resulted… (More)
DOI: 10.1038/clpt.2009.233


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