Intravenous thrombolytic therapy for acute ischemic stroke.

@article{Wechsler2011IntravenousTT,
  title={Intravenous thrombolytic therapy for acute ischemic stroke.},
  author={Lawrence R. Wechsler},
  journal={The New England journal of medicine},
  year={2011},
  volume={364 22},
  pages={
          2138-46
        }
}
  • L. Wechsler
  • Published 1 June 2011
  • Medicine
  • The New England journal of medicine
An 81-year-old man presents to the ER with an acute ischemic stroke; IV thrombolytic therapy is recommended. Administered as a therapeutic agent within 4.5 hours after stroke, tissue plasminogen activator has been shown to improve neurologic outcomes. 
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43 Citations
Background Citations
3
Results Citations
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43 Citations

Citation Type

Citation Type

Clinical characteristics and risk score for poor clinical outcome of acute ischemic stroke patients treated with intravenous thrombolysis therapy
TLDR
Clinical characteristics of stroke patients are investigated and predictors for poor clinical outcome in response to t‐PA treatment are determined.
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Safety of carotid endarterectomy after intravenous thrombolysis for acute ischaemic stroke : a case-controlled multicentre registry study
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Patients who have suffered a stroke are often left with a high incidence of physical and psychosocial impairments. Institutions must develop and implement clinical protocols and pathways to quickly…
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The aggregate data from the 21 reported series suggest that CEA can be performed safely within the first 14 days after the onset of neurologic symptoms in patients receiving antecedent IVT, however, data regarding the safety of urgent CEA within 48 to 72 hours of thrombolysis is conflicting.
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The most reliable predictors of a “malignant” course for a large hemispheric infarction are hypodensity in more than 50 % of the MCA territory as well as stroke volume >145 mL on diffusion-weighted imaging.
Better Characterization of Transient Ischemic Attack Might Improve the Benefit: Risk Profile of Thrombolysis
  • O. Jolobe
  • Medicine
    Journal of the American Geriatrics Society
  • 2012
TLDR
By excluding cerebral infarction, MRI might also mitigate the risk of inappropriate thrombolysis in individuals who present with TIA in the presence of cerebral amyloid angiopathy (CAA), given that CAA has its highest prevalence in that age group.
Acute Stroke Care and Thrombolytic Therapy Use in a Tertiary Care Center in Lebanon
TLDR
In this setting, rt-PA utilization was higher than expected and public education regarding stroke is needed to decrease time from symptoms onset to ED presentation and potentially improve outcomes further.
Very Early Carotid Endarterectomy After Intravenous Thrombolysis.
  • C. Azzini, M. Gentile, +5 authors I. Casetta
  • Medicine
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery
  • 2016
TLDR
This experience suggests that very early CEA after thrombolysis, aimed at removing the source of potential embolisation and restoring blood flow, may be safe and can lead to a favourable outcome.
Is there Still a Time Window in the Treatment of Acute Stroke?
TLDR
Defining a patient-based therapeutic window to replace strict time windows and therefore refining patient exclusion and inclusion criteria is possible through understanding pathophysiology of acute ischemic stroke in individual patients.
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