Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS)

@article{Hacke1995IntravenousTW,
  title={Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS)},
  author={Werner Hacke and Markku Kaste and Cesare Fieschi and Danilo S Toni and Emmanuel Lesaffre and R{\"u}diger von Kummer and Gudrun Boysen and Erich Bluhmki and Godehard Hoexter and Marie H{\'e}l{\`e}ne Mahagne},
  journal={JAMA},
  year={1995},
  volume={274 13},
  pages={1017-25}
}
OBJECTIVE To evaluate the efficacy and safety of intravenous thrombolysis using recombinant tissue plasminogen activator (rt-PA) in patients with acute ischemic stroke. DESIGN Randomized, prospective, multicenter, double-blind, placebo-controlled clinical trial. SETTING A total of 75 hospitals in 14 European countries. PATIENTS A total of 620 patients with acute ischemic hemispheric stroke and moderate to severe neurologic deficit and without major early infarct signs on initial computed… CONTINUE READING
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