Intravenous tPA Therapy Does Not Worsen Acute Intracerebral Hemorrhage in Mice

@inproceedings{Foerch2013IntravenousTT,
  title={Intravenous tPA Therapy Does Not Worsen Acute Intracerebral Hemorrhage in Mice},
  author={Christian Foerch and Nathanael L. Rosidi and Frieder Schlunk and A Lauer and Flor A. Cianchetti and Emiri T. Mandeville and Ken Arai and Kazim Yigitkanli and Xiang Fan and Xiaoying Wang and Klaus van Leyen and Helmuth H. Steinmetz and Chris B. Schaffer and Eng H. Lo},
  booktitle={PloS one},
  year={2013}
}
Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral hemorrhage (ICH). Surprisingly, however, the assumption that tPA will worsen ICH has never been biologically tested. Here, we assessed the effects of tPA in two models of ICH. In a mouse model of collagenase-induced ICH, hemorrhage volumes and neurological deficits after 24… CONTINUE READING