Intravenous somatic gene transfer with antisense tissue factor restores blood flow by reducing tumor necrosis factor-induced tissue factor expression and fibrin deposition in mouse meth-A sarcoma.

@article{Zhang1996IntravenousSG,
  title={Intravenous somatic gene transfer with antisense tissue factor restores blood flow by reducing tumor necrosis factor-induced tissue factor expression and fibrin deposition in mouse meth-A sarcoma.},
  author={Yan Zhang and Yong Deng and Thoralf Wendt and Birgit Liliensiek and Angelika Bierhaus and Johannes Greten and Wei He and Bingkun Chen and Viola Hach-Wunderle and Ruediger Waldherr and Reinhard Ziegler and Daniela M{\"a}nnel and David M. Stern and Peter P Nawroth},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 10},
  pages={2213-24}
}
Fibrin is deposited on the endothelial cell surface in the vasculature of murine methylcholanthrene A-induced sarcomas after injection of tumor necrosis factor (TNF). Capillary endothelial cells of the tumor vascular bed become positive for tissue factor after TNF injection, based on immunocytochemistry and in situ hybridization. Intravascular clot formation was not dependent on tissue factor derived from tumor cells, since in vessels of tumors not expressing tissue factor, TNF also induced… CONTINUE READING

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