Intravenous sildenafil in the treatment of neonates with persistent pulmonary hypertension.

  title={Intravenous sildenafil in the treatment of neonates with persistent pulmonary hypertension.},
  author={Robin Heise Steinhorn and John P. Kinsella and Christine Pierce and Ghazwan S. Butrous and Maria Dilleen and Michael Oakes and David L. Wessel},
  journal={The Journal of pediatrics},
  volume={155 6},
OBJECTIVE To evaluate the safety of intravenous (IV) sildenafil, an inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase, in treating near-term and term newborns with persistent pulmonary hypertension of the newborn (PPHN). STUDY DESIGN This was an open-label, dose-escalation trial in newborns with PPHN and an oxygenation index (OI) > 15. Sildenafil was delivered by continuous IV infusion for at least 48 hours and up to 7 days. RESULTS Five centers enrolled a total of 36… CONTINUE READING


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