Intravenous self-administration of amphetamine is increased in a rat model of depression.

@article{Holmes2002IntravenousSO,
  title={Intravenous self-administration of amphetamine is increased in a rat model of depression.},
  author={Philip V. Holmes and Cher V. Masini and Stefany D. Primeaux and Joshua L. Garrett and Andrew S Zellner and Kimberly S Stogner and Alicia A Duncan and Jonathon D. Crystal},
  journal={Synapse},
  year={2002},
  volume={46 1},
  pages={4-10}
}
Affective disorders and substance abuse frequently coexist, yet few previous studies have examined drug self-administration using animal models of depression. The olfactory-bulbectomized rat is a well-established model that exhibits a high degree of neurochemical similarity to depression. Olfactory bulbectomy (OBX) increases dopamine receptor densities in the ventral striatum, which may increase the reinforcing effects of drugs of abuse. Experiments were designed to test the hypotheses that… CONTINUE READING

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