Intravenous self-administration of γ-hydroxybutyrate (GHB) in baboons.

  title={Intravenous self-administration of γ-hydroxybutyrate (GHB) in baboons.},
  author={Amy K. Goodwin and Barbara J. Kaminski and Roland R Griffiths and Nancy A. Ator and Elise M Weerts},
  journal={Drug and alcohol dependence},
  volume={114 2-3},
BACKGROUND Abuse of gamma-hydroxybutyrate (GHB) poses a public health concern. In previous studies, intravenous (IV) self-administration of GHB doses up to 10 mg/kg was not maintained in non-human primates under limited-access conditions, which was inconsistent with the usual good correspondence between drugs abused by humans and those self-injected by laboratory animals. METHODS Self-administration of GHB was studied in 10 baboons using procedures standard for our laboratory to assess drug… CONTINUE READING
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