Intravenous self‐administration of benzydamine, a non‐steroidal anti‐inflammatory drug with a central cannabinoidergic mechanism of action

  title={Intravenous self‐administration of benzydamine, a non‐steroidal anti‐inflammatory drug with a central cannabinoidergic mechanism of action},
  author={Riccardo Avvisati and Maria Meringolo and Emiliana Stendardo and Elisa Malavasi and Silvia Marinelli and Aldo Badiani},
  journal={Addiction Biology},
  pages={610 - 619}
Benzydamine (BZY) is a non‐steroidal anti‐inflammatory drug used for the topical treatment of inflammations of the oral and vaginal mucosae. Virtually nothing is known about the central pharmacological actions of BZY. Yet there are reports of voluntary systemic overdosage of BZY in drug addicts, resulting in a euphoric, hallucinatory state. In the present study, we investigated the reinforcing properties of BZY in a rat self‐administration paradigm. We found that BZY has a powerful reinforcing… 
Chronic psychosis related to benzydamine hydrochloride abuse
This is the only case in which psychosis was still present despite discontinuation of the benzydamine hydrochloride drug, and the aim was to contribute to the literature on the use of BH in causing chronic psychosis and to draw attention to the growing number of B H abuse cases.
The Benzydamine Experience: A Systematic Review of Benzydamine Abuse
Results from the systematic review showed BZY might be diverted for typical hallucinogenic properties occurring at high dosages, and healthcare professionals should be warned about a possible misuse/abuse of a commonly prescribed anti-inflammatory drug and be vigilant when prescribing it.
Reversion of antibiotic resistance in drug-resistant bacteria using non-steroidal anti-inflammatory drug benzydamine
Findings revealed that benzydamine is a promising tetracycline antibiotics adjuvant and has the potential to address life-threatening infections by multidrug-resistant bacteria.
Reversion of antibiotic resistance in multidrug-resistant pathogens using non-antibiotic pharmaceutical benzydamine
Findings indicate that benzydamine is a potential tetracyclines adjuvant to address life-threatening infections by MDR bacteria.
Understanding the use of prescription and OTC drugs in obtaining illicit highs and the pharmacist role in preventing abuse
This is accepted text of Understanding the use of prescription and OTC drugs in obtaining illicit highs and the pharmacist role in preventing abuse. The Pharmaceutical Journal, Vol 305, No 7943,


3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") and its stereoisomers as reinforcers in rhesus monkeys: serotonergic involvement
MDMA and its stereoisomers serve as reinforcers in rhesus monkeys and it is suggested that stimulation of 5-HT2A receptors is integral to the reinforcing effects of MDMA.
Cocaine self-administration differentially modulates the expression of endogenous cannabinoid system-related proteins in the hippocampus of Lewis vs. Fischer 344 rats.
The findings indicate that cocaine may regulate hippocampal GABA/glutamate synapses by directly modulating endocannabinoid production/degradation enzymes and that these actions are strain-dependent.
Pharmacology of benzydamine
Benzydamine is a topical anti-inflammatory drug which is widely available and used topically for the treatment of the mouth. It is also used as a gel for application to inflamed joints. It has
An anti-inflammatory as a recreational drug in Brazil.
The benzydamine recreational use among 2.3% of a sample of 5208 students of Sao Paulo, the largest city of Brazil, is identified, with the main characteristic of belonging to the wealthiest socioeconomic status of the country.
Reinforcing Effects of MDMA (‘Ecstasy’) in Drug-Naive and Cocaine-Trained Rats
When MDMA was tested after cocaine, there was no carryover of cocaine’s reinforcing effect to that of MDMA, suggesting that MDMA and cocaine produce distinct interoceptive stimuli in rats.
Effect of benzydamine, a topically administered NSAID onin vitro prostanoid synthesis by human and rat gastric mucosa and rat kidney, aorta and urinary bladder: Lack of effect on cyclooxygenase but potent inhibition of receptor-linked prostanoid synthesis
Benzydamine is unlikely to elicit cyclooxygenase-mediated side-effects on the gastrointestinal tract or kidney, and the anti-inflammatory action of benzydamines is mediated by disruption of calcium linked to receptor-PG synthesis coupling, and calcium-dependent inflammatory processes may also be affected by benzydamine.
Opposite environmental regulation of heroin and amphetamine self-administration in the rat
It is demonstrated that even in the laboratory rat some contexts are associated with the propensity to self-administer more opioid than psychostimulant drugs and vice versa, indicating that drug taking is influenced not only by economical or cultural factors but also can be modulated at a much more basic level by the setting in which drugs are experienced.
Self-administration of psychoactive substances by the monkey
In the present study monkeys developed psychological dependence on morphine, codeine, cocaine, d-amphetamine, pentobarbital, ethanol, and caffeine, and all of these drugs except caffeine produced psychotoxicity.
Development, maintenance and temporal pattern of self-administration maintained by ecstasy (MDMA) in rats
The results suggest that MDMA has abuse liability and that increased use of the drug should raise concern of a growing and widespread potential for chronic abuse.
Mediation of Amphetamine-Induced Long-Term Depression of Synaptic Transmission by CB1 Cannabinoid Receptors in the Rat Amygdala
It is shown that amphetamine induces long-term synaptic depression in the amygdala, and the results suggest that Amphetamine-induced endocannabinoid release depends on a rise in intracellular calcium and the incomplete block of LTD in some neurons may be attributable to the spillover of endoc cannabinoid from nearby cells.