Intravenous self‐administration of benzydamine, a non‐steroidal anti‐inflammatory drug with a central cannabinoidergic mechanism of action

@article{Avvisati2018IntravenousSO,
  title={Intravenous self‐administration of benzydamine, a non‐steroidal anti‐inflammatory drug with a central cannabinoidergic mechanism of action},
  author={Riccardo Avvisati and Maria Meringolo and Emiliana Stendardo and Elisa Malavasi and Silvia Marinelli and Aldo Badiani},
  journal={Addiction Biology},
  year={2018},
  volume={23},
  pages={610 - 619}
}
Benzydamine (BZY) is a non‐steroidal anti‐inflammatory drug used for the topical treatment of inflammations of the oral and vaginal mucosae. Virtually nothing is known about the central pharmacological actions of BZY. Yet there are reports of voluntary systemic overdosage of BZY in drug addicts, resulting in a euphoric, hallucinatory state. In the present study, we investigated the reinforcing properties of BZY in a rat self‐administration paradigm. We found that BZY has a powerful reinforcing… 
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