Intravenous salbutamol for childhood asthma: evidence-based medicine?

@article{Starkey2014IntravenousSF,
  title={Intravenous salbutamol for childhood asthma: evidence-based medicine?},
  author={Elizabeth Starkey and Hussain Mulla and Helen M. Sammons and H C Pandya},
  journal={Archives of Disease in Childhood},
  year={2014},
  volume={99},
  pages={873 - 877}
}
Intravenous salbutamol is commonly used to treat children with severe asthma unresponsive to inhaled β2-agonist therapy. However, in this setting, there is little clinical trial data demonstrating its effectiveness. Additionally, there are significant concerns that intravenous salbutamol-dosing recommendations for children with acute asthma are excessive, and unnecessarily raise the potential for adverse reactions, such as lactic acidosis and tachycardia which, by increasing respiratory… Expand
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References

SHOWING 1-10 OF 44 REFERENCES
Comparison of intravenous aminophylline and salbutamol in severe asthma.
TLDR
Results are reported with singleand double-blind comparative trials of intravenous aminophylline and salbutamol on 50 patients with severe asthma. Expand
Intravenous salbutamol: too much of a good thing?
  • A. Tobin
  • Medicine
  • Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine
  • 2005
TLDR
Systemic salbutamol has metabolic effects that may worsen respiratory function in asthma and should not be given by intravenous infusion to asthma patients outside of clinical trials. Expand
Randomised trial of intravenous salbutamol in early management of acute severe asthma in children
TLDR
Addition of a 10 min infusion of salbutamol in the early treatment of children with acute severe asthma has the potential to curtail the clinical progression of asthma, reduce demand placed on hospital resources, and improve the quality of health care provided to the acutely sick child with asthma. Expand
Intravenous salbutamol in the treatment of status asthmaticus in children
TLDR
Salbutamol was found to be a safe and effective bronchodilator capable of reversing severe bronchospasm in most children who would otherwise require mechanical ventilation, and its greater specificity for beta2-receptors may make it preferable to isoproterenol. Expand
Intravenous beta2-agonists for acute asthma in the emergency department.
TLDR
There is no evidence to support the use of IV beta2-agonists in patients with severe acute asthma and these drugs should be given by inhalation. Expand
Intravenous salbutamol bolus compared with an aminophylline infusion in children with severe asthma: a randomised controlled trial
TLDR
In severe childhood asthma, there is no significant difference in the effectiveness of a bolus of salbutamol and an aminophylline infusion in the first 2 hours of treatment. Expand
Respiratory response and pharmacokinetics of intravenous salbutamol in infants with bronchopulmonary dysplasia
TLDR
Evidence is provided that preterm infants have measurable activity of bronchiolar β2 receptor responsive to salbutamol, and Elimination half-time appears to be dictated in these infants more by the distribution volume (Vd) than by clearance (C1). Expand
The administration of beta2-agonists for paediatric asthma and its adverse reaction in Australian and New Zealand emergency departments: a cross-sectional survey.
  • D. Habashy, L. Lam, G. Browne
  • Medicine
  • European journal of emergency medicine : official journal of the European Society for Emergency Medicine
  • 2003
TLDR
A wide variation of salbutamol use in paediatric emergency departments and a high prevalence of type A adverse drug reactions when continuous-infusion intravenous sal butamol therapy was administered are reported. Expand
Intravenous infusion of salbutamol in the treatment of asthma.
TLDR
It is concluded that i.v. infusion of salbutamol may be a useful addition to the treatment of the patient with a severe attack of asthma. Expand
Intravenous beta agonist in severe acute asthma.
TLDR
Intravenous sal butamol is more effective than nebulised salbutamol in acute severe asthma but may have unacceptable cardiovascular effects. Expand
...
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2
3
4
5
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