Intravenous pulse cyclophosphamide in the treatment of interstitial lung disease due to collagen vascular diseases.

@article{Schnabel1998IntravenousPC,
  title={Intravenous pulse cyclophosphamide in the treatment of interstitial lung disease due to collagen vascular diseases.},
  author={Armin Schnabel and Michael Reuter and Wolfgang Ludwig Gross},
  journal={Arthritis and rheumatism},
  year={1998},
  volume={41 7},
  pages={1215-20}
}
OBJECTIVE Substantial toxicity limits the use of daily oral cyclophosphamide (CYC) for the treatment of interstitial lung disease (ILD) due to collagen vascular diseases. We examined whether intravenous (i.v.) pulse CYC can be substituted for daily oral therapy. METHODS Six patients with rapidly progressive ILD due to polymyositis, systemic sclerosis, systemic lupus erythematosus, or primary Sjögren's syndrome received 6-9 cycles of i.v. pulse CYC (0.5 gm/m2 of body surface area), together… CONTINUE READING
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