Intravenous pharmacokinetics, oral bioavailability, dose proportionality and in situ permeability of anti-malarial lumefantrine in rats

@inproceedings{Wahajuddin2011IntravenousPO,
  title={Intravenous pharmacokinetics, oral bioavailability, dose proportionality and in situ permeability of anti-malarial lumefantrine in rats},
  author={Wahajuddin and Sheelendra Pratap Singh and Kanumuri S R Raju and Asad Nafis and Sunil K. Puri and Girish Kumar Jain},
  booktitle={Malaria Journal},
  year={2011}
}
Despite the wide spread use of lumefantrine, there is no study reporting the detailed preclinical pharmacokinetics of lumefantrine. For the development of newer anti-malarial combination(s) and selection of better partner drugs, it is long felt need to understand the detailed preclinical pharmacokinetics of lumefantrine in preclinical experimental animal species. The focus of present study is to report bioavailability, pharmacokinetics, dose linearity and permeability of lumefantrine in rats. A… CONTINUE READING