Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells.

@article{Peters2007IntravenousPA,
  title={Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells.},
  author={Christopher M. Peters and Juan Miguel Jim{\'e}nez-Andrade and Beth M Jonas and Molly A Sevcik and Nathan J Koewler and Joseph R. Ghilardi and Gilbert Y Wong and Patrick W Mantyh},
  journal={Experimental neurology},
  year={2007},
  volume={203 1},
  pages={42-54}
}
Paclitaxel-induced peripheral neuropathy (PN) can be a significant problem for patients receiving chemotherapeutic regimens for the treatment of breast, ovarian, and lung cancer as PN can influence the quality of life and survivorship in these patients. To begin to understand the cellular changes that occur within the peripheral and central nervous system as PN develops, we intravenously infused rats with clinically relevant doses of paclitaxel. Ten days later, behavioral changes indicative of… CONTINUE READING
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