Intravenous naftidrofuryl for critical limb ischaemia.

  title={Intravenous naftidrofuryl for critical limb ischaemia.},
  author={F. Beckley Smith and Andrew W Bradbury and Francis Gerry R. Fowkes},
  journal={The Cochrane database of systematic reviews},
BACKGROUND Peripheral arterial disease affects 5% of men and women by late middle age. In approximately 25% of those affected the condition will progress to critical limb ischaemia (rest pain, ulceration and gangrene) within five years. The vasoactive drug naftidrofuryl is a serotononergic receptor antagonist which may be beneficial in the treatment of severe lower limb disease such as critical limb ischaemia. OBJECTIVES To determine whether the vasoactive drug, naftidrofuryl, when… CONTINUE READING


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