Intravenous minocycline in acute stroke: a randomized, controlled pilot study and meta-analysis.

@article{Kohler2013IntravenousMI,
  title={Intravenous minocycline in acute stroke: a randomized, controlled pilot study and meta-analysis.},
  author={Edith Kohler and David A. Prentice and Timothy R. Bates and Graeme J. Hankey and Anne Claxton and J van Heerden and David Blacker},
  journal={Stroke},
  year={2013},
  volume={44 9},
  pages={
          2493-9
        }
}
BACKGROUND AND PURPOSE Minocycline, in animal models and 2 small randomized controlled human trials, is a promising neuroprotective agent in acute stroke. We analyzed the efficacy and safety of intravenous minocycline in acute ischemic and hemorrhagic stroke. METHODS A multicenter prospective randomized open-label blinded end point evaluation pilot study of minocycline 100 mg administered intravenously, commenced within 24 hours of onset of stroke, and continued 12 hourly for a total of 5… CONTINUE READING
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