Intravenous magnesium sulphate for aneurysmal subarachnoid hemorrhage (IMASH): a randomized, double-blinded, placebo-controlled, multicenter phase III trial.

@article{Wong2010IntravenousMS,
  title={Intravenous magnesium sulphate for aneurysmal subarachnoid hemorrhage (IMASH): a randomized, double-blinded, placebo-controlled, multicenter phase III trial.},
  author={G K C Wong and Wai Sang Poon and Matthew T. V. Chan and Ronald Boet and Tony Gin and Stephanie Chi Ping Ng and Beny C. Y. Zee},
  journal={Stroke},
  year={2010},
  volume={41 5},
  pages={
          921-6
        }
}
BACKGROUND AND PURPOSE Pilot clinical trials using magnesium sulfate in patients with acute aneurysmal subarachnoid hemorrhage have reported trends toward improvement in clinical outcomes. This Phase III study aimed to compare intravenous magnesium sulfate infusion with saline placebo among such patients. METHODS We recruited patients with aneurysmal subarachnoid hemorrhage within 48 hours of onset from 10 participating centers. The patients were randomly assigned to magnesium sulfate… CONTINUE READING

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