Intravenous magnesium sulfate enhances the ability of dofetilide to successfully cardiovert atrial fibrillation or flutter: results of the Dofetilide and Intravenous Magnesium Evaluation.

@article{Coleman2009IntravenousMS,
  title={Intravenous magnesium sulfate enhances the ability of dofetilide to successfully cardiovert atrial fibrillation or flutter: results of the Dofetilide and Intravenous Magnesium Evaluation.},
  author={Craig I. Coleman and Nitesh A. Sood and Dhruv Chawla and Ripple Talati and Abhijit Ghatak and Jeffrey Kluger},
  journal={Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology},
  year={2009},
  volume={11 7},
  pages={
          892-5
        }
}
  • C. Coleman, N. Sood, +3 authors J. Kluger
  • Published 2009
  • Medicine
  • Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
AIMS A previous study found that the adjunctive use of intravenous magnesium sulfate with ibutilide could increase the odds of a patient chemically cardioverting from atrial fibrillation (AF) or flutter (AFL) to normal sinus rhythm (NSR) by 78%. Whether or not intravenous magnesium has the same effect on dofetilide's ability to chemically cardiovert patients from AF/AFL to NSR is not known. METHODS AND RESULTS This was a retrospective cohort evaluation of consecutive eligible patients… Expand
Effect of high doses of magnesium on converting ibutilide to a safe and more effective agent.
TLDR
The administration of high doses of magnesium probably makes ib utilide a much safer agent, and magnesium increased the conversion efficacy of ibutilide. Expand
Efficacy of Intravenous Magnesium in Facilitating Cardioversion of Atrial Fibrillation
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In patients undergoing electric cardioversion for persistent atrial fibrillation, Mg infusion does not increase the rate of successful cardioversion. Expand
Enhanced efficacy with MgSO4 due to an additive, alternative, or dual mode of action?
  • M. Vos
  • Medicine
  • Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
  • 2009
TLDR
It is demonstrated that a single or repeated bolus of Mg did not only protect for drug-induced adverse effects, but also improved the efficacy of dofetilide to suppress/prevent AF–AFl: 38% without vs. 50% with Mg, P < 0.05. Expand
Efficacy of class III antiarrhythmics and magnesium combination therapy for atrial fibrillation
TLDR
Magnesium may be used as adjunct for dofetilide and ibutilide due to potential improved efficacy and minimal toxicity and dose ranging studies should be conducted in the future to establish the optimal dose and duration of therapy. Expand
Intraoperative Magnesium Administration Does Not Reduce Postoperative Atrial Fibrillation After Cardiac Surgery
TLDR
High-dose intraoperative Mg therapy did not decrease the incidence of new-onset POAF after cardiac surgery, and no significant effect of Mg was found in logistic regression analysis after adjusting for AF risk. Expand
Dofetilide induced torsade de pointes: mechanism, risk factors and management strategies.
TLDR
The underlying mechanism, risk factors and precautionary measures to avoid dofetilide induced QT prolongation and ventricular tachycardia/Tdp are discussed and a scheme for the management of QT prolongedation, ventricular arrhythmia and Tdp is suggested. Expand
Magnesium for Atrial Fibrillation, Myth or Magic?
  • D. Kotecha
  • Medicine
  • Circulation. Arrhythmia and electrophysiology
  • 2016
Low magnesium levels have been implicated as a risk factor for the development of atrial fibrillation (AF).1 However, like many interventions before it, supplementing magnesium levels does notExpand
Magnesium Adjunctive Therapy in Atrial Arrhythmias
TLDR
Mg enhances the balance of benefits to harms by enhancing atrial antiarrhythmic efficacy and reducing antiarr hythmia potential when used as monotherapy in patients undergoing cardiothoracic surgery. Expand
Treating arrhythmias with adjunctive magnesium: identifying future research directions
  • W. Baker
  • Medicine
  • European heart journal. Cardiovascular pharmacotherapy
  • 2017
TLDR
A number of limitations and gaps to the literature exist, including an unclear link between correction of intracellular magnesium concentrations and both mechanistic and clinical outcomes, small sample sizes, varying routes of administration and doses, as well as short follow-up periods are highlighted. Expand
Magnesium—Essentials for Anesthesiologists
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An overview of current knowledge and available evidence with respect to physiologic aspects of magnesium and proposed indications and recommendations for its use in the clinical setting is provided. Expand
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