Intravenous lacosamide as short-term replacement for oral lacosamide in partial-onset seizures.

@article{Krauss2010IntravenousLA,
  title={Intravenous lacosamide as short-term replacement for oral lacosamide in partial-onset seizures.},
  author={Gregory L. Krauss and Elinor Ben-Menachem and Rūta Mameni{\vs}kienė and Nerija Vai{\vc}ienė-Magistris and Melissa Brock and John G Whitesides and Martin E. Johnson},
  journal={Epilepsia},
  year={2010},
  volume={51 6},
  pages={951-7}
}
PURPOSE Lacosamide is a new antiepileptic drug effective for adjunctive treatment of partial-onset seizures. We evaluated the safety and tolerability of an intravenous (i.v.) formulation of lacosamide (200-800 mg/day) infused over 10, 15, and 30 min as short-term replacement for oral lacosamide in patients with partial-onset seizures. METHODS This multicenter, open-label, inpatient trial enrolled 160 patients from ongoing open-label, long-term trials who were taking stable doses of oral… CONTINUE READING