Intravenous injection of guanylin induces mucus secretion from goblet cells in rat duodenal crypts

Abstract

 Guanylin, structurally related to the heat-stable enterotoxin of E. coli, is a 15-amino-acid peptide isolated from rat small intestine. We investigated the morphological effects of an intravenous injection of rat and human guanylin upon the rat intestine. Various doses of rat guanylin were injected intravenously in anesthetized rats. After 5, 10 and 30 min… (More)
DOI: 10.1007/s004290050146

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