Intravenous infusion of the NMDA antagonist, ketamine, in chronic posttraumatic pain with allodynia: a double-blind comparison to alfentanil and placebo.

@article{Max1995IntravenousIO,
  title={Intravenous infusion of the NMDA antagonist, ketamine, in chronic posttraumatic pain with allodynia: a double-blind comparison to alfentanil and placebo.},
  author={Mitchell B. Max and Michael G Byas-Smith and Richard H. Gracely and Gary J. Bennett},
  journal={Clinical neuropharmacology},
  year={1995},
  volume={18 4},
  pages={360-8}
}
NMDA antagonists and opioids relieve experimentally produced hyperalgesia in animals and humans, presumably by attenuating a heightened central nervous system response to afferent input. A few small studies in patients have suggested that intravenous boluses or rapid infusions of the N-methyl-D-aspartate (NMDA) antagonist ketamine relieve some neuropathic pains but also produce disturbances of cognition and mood. In a randomized, double-blind, crossover trial, we treated eight patients with… CONTINUE READING

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