Intravenous infusion of dexmedetomidine can prevent the degeneration of spinal ventral neurons induced by intrathecal morphine after a noninjurious interval of spinal cord ischemia in rats.

@article{Kakinohana2007IntravenousIO,
  title={Intravenous infusion of dexmedetomidine can prevent the degeneration of spinal ventral neurons induced by intrathecal morphine after a noninjurious interval of spinal cord ischemia in rats.},
  author={Manabu Kakinohana and Masakatsu Oshiro and Satoko Saikawa and Seiya Nakamura and Tatsuya Higa and Kenneth J Davison and Martin Marsala and Kazuhiro Sugahara},
  journal={Anesthesia and analgesia},
  year={2007},
  volume={105 4},
  pages={1086-93, table of contents}
}
BACKGROUND In recent studies, we demonstrated that neuraxial morphine after noninjurious spinal cord ischemia in the rat could induce spastic paraplegia and degeneration of selective spinal ventral neurons. Our objective was to investigate the impact of dexmedetomidine infusion on the degeneration of spinal ventral neurons induced by intrathecal (IT) morphine after spinal cord ischemia. METHODS Male Sprague-Dawley rats were given repetitive doses of IT morphine (40 microg x 2) at 1 and 5 h… CONTINUE READING