Intravenous immunoglobulin therapy in amyotrophic lateral sclerosis

  title={Intravenous immunoglobulin therapy in amyotrophic lateral sclerosis},
  author={Nicoletta Meucci and Eduardo Nobile-Orazio},
  journal={Journal of Neurology},
Seven consecutive patients with amyotrophic lateral sclerosis (ALS) were treated with intravenous immunoglobulins (IVIg; 0.4 g/kg per day for 5 consecutive days followed by monthly 2-day infusions at the same daily dosage) continued with oral cyclophosphamide (1–2 mg/kg per day), for 4–13 months (mean 8.1). Response to treatment was assessed by means of the Medical Research Council (MRC) rating scale for muscle strength on 40 muscles (10 per limb), a clinical scale for bulbar function and a… CONTINUE READING