Intravenous immunoglobulin protects neurons against amyloid beta-peptide toxicity and ischemic stroke by attenuating multiple cell death pathways.

@article{Widiapradja2012IntravenousIP,
  title={Intravenous immunoglobulin protects neurons against amyloid beta-peptide toxicity and ischemic stroke by attenuating multiple cell death pathways.},
  author={Alexander Widiapradja and Viktor Vegh and Ker Zhing Lok and Silvia Manzanero and John Thundyil and Mathias Gelderblom and Yi-lin Cheng and Dale Pavlovski and Sung-chun Tang and D H Jo and Tim Magnus and Sic Lung Chan and Christopher G Sobey and David C. Reutens and Milan Basta and Mark P. Mattson and Thiruma Valavan Arumugam},
  journal={Journal of neurochemistry},
  year={2012},
  volume={122 2},
  pages={321-32}
}
Intravenous immunoglobulin (IVIg) preparations obtained by fractionating blood plasma, are increasingly being used increasingly as an effective therapeutic agent in treatment of several inflammatory diseases. Its use as a potential therapeutic agent for treatment of stroke and Alzheimer's disease has been proposed, but little is known about the neuroprotective mechanisms of IVIg. In this study, we investigated the effect of IVIg on downstream signaling pathways that are involved in neuronal… CONTINUE READING
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