Intravenous immunoglobulin exerts reciprocal regulation of Th1/Th17 cells and regulatory T cells in Guillain-Barré syndrome patients.

@article{Maddur2014IntravenousIE,
  title={Intravenous immunoglobulin exerts reciprocal regulation of Th1/Th17 cells and regulatory T cells in Guillain-Barr{\'e} syndrome patients.},
  author={Mohan S Maddur and Magalie Rabin and P. Nidhi Hegde and Francis Bolgert and Moneger Guy and Jean-michel Vallat and Laurent Magy and Jagadeesh Bayry and Srini V Kaveri},
  journal={Immunologic research},
  year={2014},
  volume={60 2-3},
  pages={320-9}
}
Guillain-Barré syndrome (GBS) is an acute, autoimmune inflammatory disorder of peripheral nervous system characterized by a severe functional motor weakness. Treatment with intravenous immunoglobulin (IVIg) is one of the approved and preferred therapeutic strategies for GBS. However, the mechanisms underlying the therapeutic benefit with IVIg in GBS are not completely understood. In the present study, we observed that GBS patients have increased frequencies of Th1 and Th17 cells, but reduced… CONTINUE READING