Intravenous immunoglobulin contains a broad repertoire of anticarbohydrate antibodies that is not restricted to the IgG2 subclass.

@article{Gunten2009IntravenousIC,
  title={Intravenous immunoglobulin contains a broad repertoire of anticarbohydrate antibodies that is not restricted to the IgG2 subclass.},
  author={Stephan von Gunten and David F. Smith and Richard D. Cummings and Stefan Riedel and Sylvia Miescher and Alexander Schaub and Robert George Crookshank Hamilton and Bruce S Bochner},
  journal={The Journal of allergy and clinical immunology},
  year={2009},
  volume={123 6},
  pages={
          1268-76.e15
        }
}
BACKGROUND Specificities for carbohydrate IgG antibodies, thought to be predominantly of the IgG2 subclass, have never been broadly examined in healthy human subjects. OBJECTIVE To examine commercial intravenous immunoglobulin (IVIG) preparations for their ability to recognize a wide range of glycans and to determine the contribution of IgG2 to the binding pattern observed. METHODS We used a glycan microarray to evaluate IVIG preparations and a control mix of similar proportions of human… CONTINUE READING
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